What people have tried on themselves, in public

1. David Sinclair

   The Harvard genetics professor David Sinclair, author of the 2019 book Lifespan, co-founder of several longevity companies including a biological-age testing company, who describes his own supplement and fasting routine in public and reports his own clock readings.

   running since 2006 one fact still to check

   What they do. By his own account (interview of 2026-09-15) he has taken resveratrol for about twenty years and NMN for at least thirteen. His routine: a daily dose of a precursor of a cell-energy molecule (NMN), resveratrol, metformin taken in alternation with his training, no breakfast beyond a few bites of yoghurt, and exercise. He has not published doses on the pages read for this record.

   What they measure. Blood markers through a testing company whose scientific board he chairs, and a biological-age clock sold by a company he co-founded; he reports the results in interviews and posts rather than as a data set.

   What they claim. That his calculated biological age has fallen for a decade or more and now runs about ten years below his calendar age; in his words, he did not expect to gain an extra decade.

   What the public record shows. Self-reported readings from tests sold by companies he advises or co-founded, with no control, no independent re-measurement and no peer review of his own case. The clocks are research tools; one of their inventors has said in coverage that such consumer readings are for fun. His own case is also the public face of products he sells, which is a reason to read it as a story about one person rather than a record. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. insidetracker.com.

   Bears on. the energy and fuel sensing branch; the measuring ageing branch.

   The notes, and what is still to check

   Not yet verified No update or qualification of his own-age claim was found in searches of 2026-10-17 or in a 2026-09-15 interview read to the point its transcript is cut off; 2025 podcasts were not checked.

   This entry is data/experiments/david-sinclair-own-regimen.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

2. Mikhail Blagosklonny

   The cancer researcher Mikhail Blagosklonny of Roswell Park, the most-cited advocate of rapamycin as a drug to slow human ageing, who wrote that he took it himself and who died of lung cancer in 2024-10 at 63.

   2010 to October 2024 2 facts still to check

   What they do. Taking rapamycin himself, by his own account irregularly and on schedules he called suboptimal for cancer prevention, while publishing for fifteen years the argument that it should be taken to slow ageing. He also wrote that he had quit smoking. He gave no dose or duration.

   What they measure. Nothing published as a self-experiment; his account is a narrative of his own cancer, written after a diagnosis of lung cancer with brain metastases in 2023-01, in which he dates a small lung shadow on an X-ray to 1991, long before he began the drug.

   What they claim. In his 2024-01 paper, that rapamycin may delay cancer but not prevent it completely, and that his own irregular use did not test the drug properly.

   What the public record shows. One person's own account in a journal he co-founded, written during treatment, with no measurements, no control and no way to separate the drug from anything else; and the outcome, his death from the cancer in 2024-10, which neither confirms nor refutes anything about rapamycin and ageing. The record is included because his case is often cited both for and against the drug, and because he himself was careful to say it proved nothing. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. oncoscience.us.

   Bears on. the energy and fuel sensing branch.

   The notes, and what is still to check

   Notes His 2019 opinion article in the journal Aging on rapamycin for longevity, read in part, contains no statement of personal use. His blog, which coverage says carried the first version of his account on 2023-10-26, no longer resolves.

   Not yet verified The start year (2010) is a guess: his 2024-01 paper says he took rapamycin irregularly and gives no start date, duration or dose, and no other first-person source was found. Find one or remove the year. The age at death (63) is from Wikipedia; the journal gives only the years 1961-2024, so 62 or 63. Find a birth date or drop the age.

   This entry is data/experiments/mikhail-blagosklonny-rapamycin.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

3. Dave Pascoe

   A retired network security engineer and massage therapist in his early sixties who has spent more than a decade on a self-designed programme to slow his own ageing, and who placed near the top of the Rejuvenation Olympics leaderboard in 2024.

   running since 2013 one fact still to check

   What they do. Daily walking, running, home workout videos, yoga and cycling intervals; whole home-cooked food; about two hundred supplements a day by his own count; prescription thyroid hormone and a low-dose statin; and procedures he pays for himself, including plasma exchange, hyperbaric oxygen, stem cell and exosome infusions, sauna and cold exposure. He says he has done it alone, without a medical team, for more than a decade.

   What they measure. Blood, urine, stool, hair and tissue tests; body scans of several kinds; wearable data; monthly hormone levels; and biological-age clocks read from blood, including the pace-of-ageing clock the Rejuvenation Olympics ranks by, all posted on his own site.

   What they claim. His own figures, undated on his page: a best clock age of 37.95 against a calendar age of 61 at the time; a current clock age of 43; a best pace of ageing of 0.66 years per calendar year; and, through a separate contest called the Longevity World Cup, what that contest calls a medically verified age reduction of 17.2 years. Coverage from 2024-01 placed him sixth on the Rejuvenation Olympics, one place above Bryan Johnson, on a budget the coverage put at about thirty thousand dollars a year; his page on 2026-10-16 gave his rank there as 92nd.

   What the public record shows. One person's commercial test results, posted by himself, with no control, no independent re-measurement and no peer review. The contest's "medically verified" label means the contest checked the tests were his, not that anyone independent measured him. His programme has changed over the years, so even his own series cannot say which part did what. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. davepascoe.net.

   Bears on. the measuring ageing branch; the inflammation and the body's messaging branch; the replacing lost cells and parts branch.

   The notes, and what is still to check

   Notes His bare domain refused connections on 2026-10-16; the www address served the page. He presented his blood results on Michael Lustgarten's channel on 2025-04-20 (michael-lustgarten).

   Not yet verified The start year is a reading of his own phrase, more than a decade, from a page written in 2024 or 2025; he gives no start date, and a podcast's show notes of 2024-08-17 name 2012 (his discovery of telomeres) as a turning point.

   This entry is data/experiments/dave-pascoe.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

4. Michael Lustgarten

   A research scientist at a nutrition research centre at Tufts University, author of some three dozen peer-reviewed papers on ageing, who since at least 2014 has published his own blood tests against his diet on a site and a video channel called Conquer Aging or Die Trying.

   running since 2014 2 facts still to check

   What they do. He eats a weighed, logged diet, takes a changing set of supplements and exercises, and runs blood panels several times a year, then publishes the correlations between what he ate and what the blood showed, adjusting the diet to move the markers. The programme is unusual in being explicitly his own data analysis rather than a bought protocol.

   What they measure. Standard blood panels, a biological-age calculation from those panels (PhenoAge, which turns nine routine blood values and calendar age into an age estimate), and from time to time clocks read from the chemical marks on DNA; all posted with the raw numbers on his site and channel. In 2025-04 he titled three posts with a biological age twenty-two years below his calendar age.

   What they claim. That his blood-panel biological age runs more than twenty years below his calendar age (post titles of 2025-04-13, 2025-04-18 and 2025-04-22), and that the correlations in his own data show which foods move which markers for him.

   What the public record shows. One person's commercial blood panels, analysed by himself, with no control and no independent check; his peer-reviewed papers are on cohorts and mice, and none that could be found publishes his own tracking data. The blood-panel age he reports is a calculation that was built to predict mortality across populations, not a measure validated for one person's change over time. His site carries affiliate discount codes. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. michaellustgarten.wordpress.com.

   Bears on. the measuring ageing branch.

   The notes, and what is still to check

   Not yet verified The start year 2014 is the earliest year of his site's archive and not a start of tracking: show notes of a podcast of 2023-11-15 give 2008 for yearly blood tests and 2015 for diet logging, from his own account, which was not heard. Find his own words or the date he began publishing his results. His job title ('Scientist II' in a 2023 podcast biography) is not confirmed by a current Tufts page: he is absent from the research centre's scientists list and his newest papers give the Friedman School of Nutrition Science and Policy as address. The paper count (36 on a PubMed author search) was not checked for namesakes.

   This entry is data/experiments/michael-lustgarten.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

5. Elizabeth Parrish

   The chief executive of BioViva, a small gene therapy company, who in 2015 at the age of 44 had two of her own company's experimental gene therapies injected into herself, outside any trial and outside the United States.

   September 2015 to September 2015

   What they do. In 2015-09 she received two gene therapies made by her company: one meant to lengthen the protective caps on chromosome ends (a telomerase gene), the other meant to protect muscle (a follistatin gene). The 2015 treatment was followed by a second dose of the telomerase gene in 2020-09, according to a 2022 case report (about one unnamed woman whose starting figures match hers); since then the company has continued measurement and publication.

   What they measure. The length of chromosome caps in white blood cells, measured by one commercial laboratory in Houston before and after; BioViva has since published follow-up measurements and, in 2022, a case report in a small journal (the Journal of Regenerative Biology and Medicine, published by Maples Publishing, 2022-03-31, written by Patrick Sewell).

   What they claim. BioViva's release of 2016-04-21 said her telomeres had lengthened by approximately twenty years, from 6.71 to 7.33 thousand base pairs, and called it the first successful gene therapy against human ageing; her own words in the release were that if the results were anywhere near accurate, history had been made.

   What the public record shows. One person, one laboratory, two time points, measured by a company reporting on its own chief executive, with no peer review at the time; the two bodies the release named as having verified the result were advocacy non-profits, not laboratories. Telomere-length tests on blood cells vary by around ten percent between measurements, which is about the size of the change reported. The release did not say where the injections were given; a magazine interview placed it in Colombia. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. fightaging.org.

   Bears on. the damaged DNA branch.

   The notes, and what is still to check

   Notes The release named telomerase and follistatin only by what they were for, not by name; the gene names are from the magazine interview and later coverage. The status is marked ended because the dosing was a single occasion in 2015-09; the measurements continued.

   This entry is data/experiments/elizabeth-parrish-bioviva.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

6. Peter Attia

   The physician and author Peter Attia, whose 2023 book Outlive and podcast The Drive reach a large audience, and who has said in public that he takes rapamycin, the drug this site tracks under energy and fuel sensing.

   running since 2018

   What they do. By his own account on a podcast recorded in 2024: eight milligrams of rapamycin once a week, for about two months at a time with a month off because of mouth ulcers, over about six years. In 2016 he had said on another podcast (released 2016-10-20) that he was not yet taking it.

   What they measure. Nothing he has published about himself beyond the regimen; he said on the same 2024 podcast that he had no idea whether he felt any effect, and that he puts little stock in biological-age clocks. His book describes a medical approach to ageing for readers, not his own data.

   What they claim. None about his own ageing. He calls rapamycin the most promising drug of its kind on the evidence from animals, and says of his own use that he does not know what it has done.

   What the public record shows. A physician taking a prescription drug off-label and saying so, with no measurement published and no claim of a result; the public record is his statement and nothing else. That is the honest version of a self-experiment, and it still moves no leaf: a claim about one person is a story, not a record, and a non-claim about one person is not a record either.

   Their own publication of it. hubermanlab.com.

   Bears on. the energy and fuel sensing branch.

   The notes, and what is still to check

   Notes His own site's 2021 article on rapamycin is about the drug's history, not his use; his book page says nothing about his own regimen.

   This entry is data/experiments/peter-attia-rapamycin.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

7. Bryan Johnson: Blueprint

   The technology entrepreneur Bryan Johnson, who founded the payments company Braintree, sold it in 2013, and since late 2021 has run a published, team-measured programme to slow his own ageing, which he calls Blueprint.

   running since 2021 one fact still to check

   What they do. A fixed daily programme of diet (vegan, measured to the calorie, eaten within a set window), exercise, sleep, dozens of supplements and several prescription drugs, all published and revised in public on his protocol page. He has added one-off procedures: a gene therapy in 2023-10, an injection of 300 million stem cells in 2024-03, hyperbaric oxygen sessions from 2024-11, and in 2023 a series of plasma exchanges, one of them with his teenage son as the donor, which he said in a post of 2023-07-05 had shown no benefit he could detect. He took rapamycin, the drug this site tracks under energy and fuel sensing, for about five years and stopped on 2024-09-28, saying in a post of 2024-11 that the side effects outweighed the benefits. In 2025-07 he said he was hiring people to run the Blueprint business so he could spend his time on his wider movement, which he calls Don't Die.

   What they measure. Hundreds of blood markers, biological-age clocks read from blood, a pace-of-ageing figure from one of those clocks (DunedinPACE, which reads the chemical marks on DNA and reports how many years of ageing a body shows per calendar year), organ-by-organ age estimates from imaging and function tests (his page gives, for example, a skin age beside his calendar age), and sleep and fitness measures, all published on his own site and in his own posts and videos.

   What they claim. That his measured pace of ageing is well below one year per year: his own figures over time are 0.76 (his post of 2023-02-01), 0.64 (a post in 2024-06, which he called a new record) and 0.50 (his entry at the top of the Rejuvenation Olympics leaderboard on 2026-10-16); that several of his organs measure younger than his calendar age; and that the programme is the best-measured attempt to slow ageing in one person. His stated aim, on the same 2023 post, was to have the biology of an eighteen-year-old.

   What the public record shows. What is published is one person's measurements, taken by his own team or by the commercial testing company that runs the leaderboard he co-founded, with no control group, no independent check and no peer review. The clocks he reports on are research tools whose meaning for one person's remaining life is not established; a change in a clock reading is not yet an accepted measure of slowed ageing, which is exactly what the measuring branch of this site tracks. The record shows a well-documented, expensive, single-person programme with striking marker results, one drug stopped for side effects, one procedure he himself judged to have done nothing, and no way to say which part of the rest, if any, did what. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. protocol.bryanjohnson.com.

   Bears on. the energy and fuel sensing branch; the inflammation and the body's messaging branch; the replacing lost cells and parts branch; the measuring ageing branch.

   The notes, and what is still to check

   Notes He co-founded the Rejuvenation Olympics leaderboard, which ranks people by their measured pace of ageing; that is its own self-experiment record (rejuvenation-olympics). His 2023-02-01 post ("Why I Am Spending Millions To Be 18 Again") was read in a repost on lifeboat.com; his site now sells the Blueprint products, and the protocol page is the part that still describes the programme.

   Not yet verified The reported spend of about two million dollars a year is from news coverage (Bloomberg, 2023-01-25); in a post of 2023-02-04 he wrote that Blueprint does not cost two million dollars a year and can be done for about 1,684 dollars a month including food.

   This entry is data/experiments/bryan-johnson-blueprint.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

8. Julie Gibson Clark

   A recruiter and former structural engineer in Phoenix, a single mother in her mid-fifties, who held second place on the Rejuvenation Olympics leaderboard in late 2023 on a budget of about a hundred dollars a month.

   running since 2023 one fact still to check

   What they do. As reported in coverage from 2023-12: about a pound of vegetables a day, four weight-training days and one core day a week, twenty to thirty minutes of cardio four times a week, a sauna three times a week followed by a cold shower, and one supplement product costing seventy-nine dollars a month, which is how her test came to be entered: through that company's trial.

   What they measure. Repeated TruDiagnostic blood tests, scored by the pace-of-ageing clock the Rejuvenation Olympics ranks by; the results appeared on that leaderboard rather than anywhere of her own.

   What they claim. A reporter's account, not her own figure: a pace of ageing of 0.665 years per calendar year (Fortune, 2023-12-09), and, in her words in a 2026-07 press release for a company she now teaches for, that ageing well is a few fundamentals done consistently.

   What the public record shows. One series of commercial tests entered through a supplement company's trial, reported by journalists and the leaderboard, with no publication of her own, no control, no independent re-measurement and no peer review. By 2026 she had left second place and was working for a longevity teaching company, so what is public is now also a professional interest. A claim about one person is a story, not a record, and it moves no leaf.

   Their own publication of it. fortune.com.

   Bears on. the measuring ageing branch.

   The notes, and what is still to check

   Notes The record layout requires a link to the person's own publication; this record has none. John ruled on 2026-10-17 that the entry stays, with the figure marked plainly as a reporter's account (the claims field says so). The alternative, dropping it and letting the Rejuvenation Olympics record carry her as a line, was not taken.

   Not yet verified Everything here is from coverage (Fortune 2023-11-04 and 2023-12-09; a NOVOS page of 2024-09-11; a podcast page of 2025-05-27; a press release of 2026-07-28); she has published nothing of her own that could be found. The start year 2023 is the year of her leaderboard place, not of her routine, which Fortune says began over a decade earlier.

   This entry is data/experiments/julie-gibson-clark.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

9. Bryan Johnson and Oliver Zolman: Rejuvenation Olympics

   A public leaderboard founded by the entrepreneur Bryan Johnson and the physician Oliver Zolman, run with the testing company TruDiagnostic, that ranks members of the public by how slowly a blood-based clock says they are ageing.

   running since 2023 one fact still to check

   What they do. Anyone aged eighteen or over buys a TruDiagnostic blood test, registers, returns the sample and consents to share the result; the site asks them to retest every three months. Two leaderboards are kept: one by pace of ageing (DunedinPACE, a clock that reads the chemical marks on DNA and reports how many years of ageing the body shows per calendar year) and one by an organ-by-organ age from Yale's system-specific clocks. A participant is marked verified after three tests within two years, and the ranking is the average of their three lowest pace scores in that time.

   What they measure. The two clock readings per test, as reported by one commercial laboratory; a rank; a verified badge based on the count of tests, not on anything independent. On 2026-10-16 the top five by pace were Bryan Johnson at 0.50, then four other verified entrants between 0.51 and 0.57.

   What they claim. That the people at the top of the board are ageing at about half the normal rate, and that the board shows what is possible for ordinary people as well as for its founder.

   What the public record shows. Every figure on the board is a self-selected person's result from one commercial test, run by one company that also sells the test, with no control group, no independent re-measurement and no peer review of the board itself. The clock it ranks by is a research tool; a low reading is not an accepted measure of slowed ageing, and the measuring branch of this site tracks exactly whether it ever becomes one. The site's own rules describe the verification: three tests in two years. No founding date is on the site; the 2023 start is from coverage. A claim about one person is a story, not a record, and a ranked list of such claims is a list of stories; it moves no leaf.

   Their own publication of it. rejuvenationolympics.com.

   Bears on. the measuring ageing branch.

   The notes, and what is still to check

   Notes Bryan Johnson's own programme is the record bryan-johnson-blueprint; Dave Pascoe's is dave-pascoe; Julie Gibson Clark, who held second place in 2023 and 2024, is julie-gibson-clark. The frequently-asked-questions page returned an error on 2026-10-16.

   Not yet verified The rules, FAQ and TruDiagnostic's own page describe only a test count and consent at kit registration; whether the lab checks a sample belongs to the named person is not stated anywhere found.

   This entry is data/experiments/rejuvenation-olympics.toml in the public repository.

   A claim about one person is a story, not a record, and it moves nothing on the tree.

The record itself is one file per person in data/experiments in the public repository. An entry missing, or a claim misread: say so.